When an aide to Mayor West is found stabbed to death, evidence that the victim attempted to blackmail the Mayor points to West and he is put on trial for murder. Despite Tom Tucker's insistence on finding a quick decision of guilty, Brian is the lone holdout voting "not guilty" and he tries to persuade his fellow jurors that there's a reasonable doubt of the Mayor's guilt. His insistence frustrates the others who don't trust the Mayor because he is a politician. Brian's examination of the evidence points to inconsistencies. Brian agrees that if no one is convinced of the possibility of innocence that he will change but the vote comes up with an agreement from Herbert that there is a chance of innocence. The other jurors just want to go home.
Bruce calls for a break and Quagmire berates Brian for not going along when he had the chance. Back in the jury room, Brian questions the witness' testimony of seeing the crime during an orgy and Quagmire tries to prove that it could really happen, but finds that Brian may be on to something when his demonstration proves that the witness could not have looked out a window during the orgy. The jury finds itself deadlocked at 6-6 and Tom Tucker still holds out for a guilty verdict until Dr. Hartman shoots him down. With just Carter as the lone holdout for guilty, Brian challenges his thought until Carter reveals that he was betrayed by the Mayor and gives in on his guilty vote. Acquitted, Mayor West resumes his duties. Back at the Griffin home, Stewie is unsatisfied that they proved Mayor West was innocent and reveals that a maniac is still on the loose. Just then the lights go out and Stewie declares they are dead.