While stopping at Goldman’s Pharmacy, Peter imitates an Excedrin commercial and buys several copies of the fashion magazine Marie Claire, only to be disappointed by the physical appearance of actress Kathleen Turner.
When LaDawn is taking Stewie to bed they pass a frame with Lois' parents although Carter's hair and mustache are already grey even though Barbara's hair is still black.
Lois’ book club reads The Lovely Bones by Alice Sebold.
As Neil tries to push himself away from Lois, he gets a handful of her breast.
One of the people Lois interviews for the babysitter for Stewie is Gloop from the 1967 TV show The Herculoids.
Before Stewie locks Jeremy in the trunk, Stewie gives him his iPod so he could listen to The Strokes while he gasps for air Stewie at first calls them “The Streeks”.
Brian and Stewie witness the infamous ipecac scene from this episode played backwards in "Yug Ylimaf".
In the joke in which Stewie makes a reference to Adolf Hitler and Eva Braun dying together, it depicts the two “performing” suicide by means of drug ingestion. In reality, Hitler shot himself and ingested a pill, while Braun just ingested a pill.
At the end of the episode Peter mentions “Next week I run for mayor of Quahog. Do I have what it takes?” No episode with this plot followed, although in "It Takes a Village Idiot, and I Married One", Lois runs for Mayor.
In the Everybody Loves Raymond cutaway, Ray refers to his wife as "Patty", even though her name in the show was Debra.
According to the DVD commentary, this is the first episode of Family Guy to make a reference to The Simpsons.
When Neil is in his "Wolverine" regalia, he is drawn without acne. Director Greg Colton tries to justify this by saying his make-up covered it up.