Angelo's is where Meg and Quagmire went on a date in "Quagmire and Meg". Quagmire pretends to be interested in Meg's schoolwork and fakes his way through answering with her on his favorite class. He also asks her about family information he is already aware of. When he suggests they should blow the joint, he is momentarily taken aback when she accepts only to find out she believed he meant to leave.
Brian meets his blind girlfriend Kate's parents over dinner at Angelo's in "The Blind Side". As Kate hates dogs, Stewie wraps Brian in bandages and passes him off as a burn victim for Kate's parents who can see fine. When events reveal Brian's true nature, Kate leaves him for lying to her and exits through an alarmed emergency exit.