The iPhone is a line of smartphones designed and marketed by Apple Inc. They run Apple's iOS mobile operating system.

In "Life of Brian", Vinny suggests that he could bring back an iPhone that "fell off a truck."

After seeing a partially undressed Patty in the girl's gym locker room in "Scammed Yankees", Stewie observes that Brian wants Patty more than he wanted the new iPhone. In a cutaway in a line outside of Rumps, a patron tries to convince Stewie that he is in the wrong store for an iPhone, but he rejects the comments as an attempt to move up in line.

In a 2017 advertisement for the iPhone 7 sticker feature, Stewie is shown on the back of a youth as he enters a diner and takes a seat with his friends. During the advertisement, “Boys are Boys and Girls are Choice” by the Monks is performed.