This episode was originally titled "Back to the Pilot", a parody of Back to the Future but was later made into a "Road to..." episode before being changed yet again to its original title.  For its December 2, 2012 rebroadcast, listings were split between both titles.
The "Death Has a Shadow" scenes are shot in 4:3 ratio to keep with the early look of the show. The current scenes are shot in 16:9.
The future scenes are rendered in CGI.
Stewie says he learned about the rules of time travel from the TV series Quantum Leap.
It turns out that, in the past, the Griffins did absolutely nothing during a cutaway. Today, they drink, smoke, and text while a cutaway occurs.
Peter is the second person to mistake Stewie's time machine for a bathroom, after Mort in "Road to Germany".
Stewie says the new American Civil War killed 17 million people including Cesar Millan, best known as the Dog Whisperer.
Even though they commented on how different things look in the past and distant future, neither Brian nor Stewie point out that hardly anyone has actually aged in spite of the years of difference.
If one version of Brian was dead, then there should have been an even number of votes since one version of Peter came with Brian and Stewie. However, Peter voted both Yes and No on 9/11.
Once again, the power of Stewie's return pad changes. It was uranium in "Road to Germany" which is referred to in the episode, plutonium in "The Big Bang Theory", and now it runs on simple household D batteries. This parodies the Back to the Future trilogy whereby the DeLorean time machine runs on plutonium in the first film and ordinary household waste via a Mr Fusion plutonium converter in the second film.
Stewie refers to Meg as sounding like "someone about to give up a huge opportunity". He is referencing Lacey Chabert, Meg's original voice actor who left after season one.
Stewie stresses to Brian not to touch anything in the past, yet Stewie himself picks up and shuffles through his Japanese children's books.
The first Harry Potter book was released in 1997, so Brian taking credit for it would be unlikely to achieve.
The time that the Pilot Griffins wait for the ice cream store cutaway to finish is a bit longer than the actual cutaway.
In the newly animated pilot scenes, Stewie's eyes are drawn larger than normal.
Lois says that a statue of Brian was going to be unveiled, however, no unveiling was seen.
Stewie notes that he was lucky to talk at all after having a circumcision.
Stewie points out mistakes made in "Death Has a Shadow" throughout the episode such as the television not being plugged in and Peter's eye appearing over his nose.
Brian points out the benefits of changing the past, which is in direct contradiction to his experience with altering the timeline in "Meet the Quagmires".
In "Big Man on Hippocampus", Stewie revealed his favorite holiday as 9/11. In this episode he was unimpressed when Brian prevented 9/11.
In "Road to Germany", when Stewie and Brian are about to enter the time machine, Stewie says that even stepping on a single bug can alter the past, but when Brian asks if it's true, Stewie replies that he can do whatever he want. Unlike this episode.
In the future you can see the statue of Brian in the distance when Stewie looks out of his bedroom window.
In an alternate reality, Cleveland returned to Quahog because things in Virginia didn't work out. Cleveland returned to Quahog and Family Guy in "He's Bla-ack!".
In the broadcast version, in reaction to Meg touching the thermostat, other fathers would appear via screen door at the Griffins house next to the window where Stewie and Brian were, but they didn't appear in this episode. However, this is present in the DVD version.