• This episode was originally produced under the title "Peter and Lois Open a Store".
  • Stewie also got drunk in "Stewie B. Goode."
  • Peter and Lois mention George Foreman's boxing career and his grill, as well as expressing surprise that he is doing better than Muhammad Ali, who beat him in 1974 to take back the heavyweight boxing title.
  • The DVD commentary for "In Harmony's Way" reported that the original idea for this episode featured Peter opening a greeting card store focusing on men.