Peter is singing 'Here comes Peter Parker...Spiderman! Spiderman!' to the 1966 Batman TV show theme song because the producers couldn't get the rights to the Spiderman theme.
It’s implied that the banner of the Wanna-Bang-Oh! says Quagmire’s Cross-Cuntry Tour after Brian points out that Quagmire’s spelling of “country” is missing an “o”.
While trying to start the Winnebago, Brian and Stewie learn the hard way that it’s equipped with a system that forces the person in the passenger seat to perform fellatio on the driver.
In that same scene, Stewie calls Peter by his real name in lieu of "the fat man" which only happens a few times throughout the series.
Meg thinks Omar Sharif is dead when she's thinking of Anthony Quinn. Both actors were in the 1962 epic film Lawrence of Arabia. Sharif actually died in July 2015.
In the desert, Stewie and Brian think they see a Dr Pepper Machine and race to it, only to find it’s a mirage and actually an RC Cola Machine.
Stewie states that his “father” having relations with Lois is more disgusting than his cousin Quark Griffin.
After Stewie begins to drive, he puts a John Deere hat and "East Bound and Down", the Smokey and the Bandit theme song, begins playing as he drives off.
Lois asks Chris who the women are in Sex and the City and Chris lists Carrie, Miranda, Samantha and Scrappy-Doo, the nephew of Scooby-Doo. Then he guessed Bosley from the campy 1970's action show Charlie's Angels, Tootie from the 1980s sitcom The Facts of Life, and singer Sheena Easton.
In a moment of self-parody, when Stewie jumps from the upper floor window of the San Francisco Park Barrington Hotel, he is shown as being "played" by a stunt man, who wears a mustache and a bald cap, in a poor disguise of Stewie. When the "stunt double" lands in the dumpster, a classic "Texas switch" is portrayed, with the real Stewie emerging from the trash.
The scene where Quagmire, still chained to the hotel bed (from when the cleaning lady left him there), turns on a porno movie so he can arouse himself to the point where he’s able to use his erect penis to call 911.
The old style intermission with the characters talking over it.
Brian and Stewie arriving in San Francisco, and the ThunderCats cut-away where Lion-O uses his Sword of Omens to spy on Cheetara in the bathroom.
The episode broadcast version ends with an announcer asking viewers rhetorical questions about the episode's events. The last line is, “Will younger viewers get this Soap reference?” It is, in fact, a parody of the 1970s soap opera comedy Soap, including the family fighting on the couch.