Barbara is a girl Chris Griffin likes, as first shown when they were students at Buddy Cianci Junior High School. She has long blond hair in two pigtails.

In "Mr. Saturday Knight", Barbara asks if the claims adjuster can return when the class pans Peter's description of his job at the Happy-Go-Lucky Toy Factory.

In "To Love and Die in Dixie", Chris gives her a bottle of Elizabeth Taylor’s brand of perfume. Trying to help her spray it on, he gets it in her eyes.

In "Long John Peter", Peter Griffin tries to set them up on a date to help Chris get over his recent breakup with Anna.

She is voiced by Rachael MacFarlane.