A poster at the start of the episode states Pawtucket Patriot Ale
Bonnie makes the point after intercourse that she had forgotten how big Joe was, to her surprise however Joe replied with the same observation, indicating that Bonnie has been pregnant for 15 years, before and during the entire time Joe had been handicapped.
Colin Farrell is seen hanging out with Stewie, as Stewie meets him after a while he blows him up with a laser gun.
While in the bar, the guys see a television promo about a new show called "Who wants to marry Corky from Life Goes On?" Life Goes On was a show that aired on ABC from 1989 to 1993. Corky, the son on the show who is played by Chris Burke, has Down Syndrome.
The musical number Joe, Quagmire, Peter and Stewie perform is "Good Morning" from the musical Singin' In The Rain.
The song playing when Pontius Pilate and Judas plan to crucify Jesus is "Sunshine Day" by The Brady Bunch.
When Dr. Hartman is searching for legs to give to Joe on his computer, one pair of legs is that of Big Bird.
When Cleveland states that he hates shows that cut away from the story for some bullcrap, he refers to Family Guy itself because of its cutaway gags.
When Joe is hollering before Joe turns the lamp after they have sex is cut when censored.
The scene when young Peter is about to start to play basketball with friends and hits puberty and says he is going to masturbate is cut in censored versions.
This episode achieves what Seth MacFarlane had considered doing on DVD commentaries by putting Dr. Hartman and Carter Pewterschmidt in the same scene together to discuss how much they sound alike.