Bewitched is an American situation comedy originally broadcast for eight seasons on ABC from 1964 to 1972, starring Elizabeth Montgomery, Dick York (1964–1969), Dick Sargent (1969–1972), Agnes Moorehead and David White. It is about a witch who marries a mortal and tries to lead the life of a typical suburban housewife. Bewitched continues to be seen throughout the world in syndication and on DVD and was the longest running supernatural themed sitcom of the 1960s–1970s era.

Peter Griffin sees Samantha, played by Montgomery in the series, in a dream in "I Never Met the Dead Man".

In "Dammit Janet!", the Stephens' nosy neighbor Gladys Kravitz yells for her husband Abner when Chris Griffin knocks a plastic reindeer off the roof of the Griffin home. Mr. Kravitz is sitting naked on the couch with a bowl of popcorn covering his genitals and points out that it took him two hours to get up the nerve to rent a porno and inquires if she is going to watch it with him.

The show appears in "The Cleveland-Loretta Quagmire" when Darrin, tired of Endora's tricks, pours holy water on her.

Stewie gets even with Will Ferrell in "Jungle Love" for a bad joke in the movie remake of the series.

Peter makes a reference to the recasting of the Darrin Stephens role from Dick York to Dick Sargent during his citizenship inquiry in "Padre de Familia", as his answer to the question regarding the discovery of America.