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Brangelina

William Bradley "Brad" Pitt (born December 18, 1963) is an American actor and producer, known for his marriage to Angelina Jolie and work in films such as Thelma & Louise, A River Runs Through It, Cool World, The Ocean's series and produced The Departed and 12 Years a Slave.

The poster promoting "Stewie Kills Lois"/"Lois Kills Stewie" is a parody of the movie poster for Mr. and Mrs. Smith, starring Brad and Jolie.

Quagmire accuses his mom of being a worse parent than Jolie and Brad in "Quagmire's Mom". The pair and completely clueless while a doctor tries to explain that their parenting has completely mess up their adopted kids.