Brenda is one of Peter Griffin's ex-girlfriends. When Peter looked her up in "Stuck Together, Torn Apart" following the decision to separate from his wife Lois on a trial basis, he paid her a visit. In the years since the two dated, she gained a lot of weight, a raspy voice from smoking, lost vision in one eye or lost the eye altogether, and got married to an unknown man. The marriage produced at least three infant children. Her youngest child was born on her doorstep when she spoke with Peter while breastfeeding two of her other children. Before the birth, she wasn't exactly sure if she was pregnant or not, although it seems her husband was sure.
Brenda is voiced by Meredith Scott Lynn.