- This marks the third appearance of James Woods and the first episode where Woods does not fall for a "Reese's Pieces" trap and gets "examined by top men" at the end.
- The episode's ending takes place in November as Stewie reveals, meaning that the next episode, "April in Quahog", takes place five months later. However, time is irrelevant since months pass in various episodes, for example nine months in "Sibling Rivalry" and an unknown amount of time in "The Perfect Castaway", and Stewie has experienced multiple Christmases, but remains one year old.
- While Peter mentions in "Back to the Woods" to Brian that they should setup the "Reese's Pieces" trap straight away at the next time Woods appears, Brian does not do so, presumably as the situation did not call for it.
- The CBS studios are modeled after the real CBS studios located at 7800 Beverly Blvd. in Los Angeles.
- A poster of Robert Pattinson from the Twilight movies can be seen in Meg's room.
- Brian pitches his pilot to CBS.
- The cast of the CBS show Two and a Half Men are seen at Brian's premiere party. Charlie Sheen guest stars as himself here.
- Quagmire appears at Brian's viewing party, even though he hates Brian, as revealed in "Jerome Is the New Black".
- The song that plays at the end of the Class Holes! episode is "Mickey's Monkey" by Smokey Robinson & The Miracles.
- The writers hired by CBS to fix Brian's script are modeled after and voiced by Alec Sulkin and Wellesley Wild.
- The DVD commentary explains that the "H" in "H. Brian Griffin" does not stand for anything and was a way to express Brian as a pretentious douche.
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