The actual set of Real Time with Bill Maher is used in a live-action scene featuring Brian with Bill Maher, Arianna Huffington and Dana Gould.
There was originally going to be a side-story with Peter and Lois getting two separate beds, but it was cut. This would later be used as the sub-plot for "Mr. and Mrs. Stewie".
Brian's complaint about grey M&M's despite the fact that the bowl is filled with colored stems from the fact that dogs are color blind.
Batman vs. Predator had already been done in 1991 and had two sequels in 1995 and 1997.
The DVD version of this episode includes an extended scene with Renee Zellweger where Brian considers doing a comedy and needs someone unfunny, not good looking and forgettable. Zellweger suggests Bradley Cooper, whom she's dating.