The opening scene of the episode parodies Mister Rogers' Neighborhood, a long running American children's television series that was created and hosted by Fred Rogers.
While on the psychiatrist's couch, Brian recounts a dream he had had the previous evening, in which he is concerned about his mortality. This was based on the film Logan's Run, which shows a society where everyone's life is ended at the age of 30. A person's age is shown by their handflower, which turns color at the appropriate moment. Brian is taking the part of a "Runner" attempting to escape his termination, having reached the critical age. Having been cornered by the guards, he points at Snoopy, remarking that he must be in his fifties.
The candy bar that Peter wants is called Middlefingers.
This is the first episode showing Brian's romantic interest in human women.
Lois is seen wearing the light blue sweater that Stewie urinated on earlier in the episode.
The Drunken Clam's bartender at the time is not the usual Horace, but a bald man with glasses seen in other episodes as an extra.
Brian is seen reading the novels Into Thin Air and Memoirs Of A Geisha.
In the wedding picture, Peter's suit is black. However, Peter's suit is blue on the actual wedding.