Joseph Frank "Buster" Keaton (October 4, 1895 – February 1, 1966) was an American actor, vaudevillian, comedian, filmmaker, stunt performer, and writer. He was best known for his silent films, in which his trademark was physical comedy with a consistently stoic, deadpan expression.

In "Stewie Is Enceinte", Peter's enthusiasm for his planned viral video with the guys make him not that they will really surprise people, just like Buster Keaton did in his first talking picture. In a cutaway, Buster describes every little detail of what he is doing to the audience , despite going through the typically silent film visual comedy of a house front collapsing around him.

Keaton is voiced by Harvey Fierstein.