Caddyshack is a 1980 American comedy film directed by Harold Ramis and written by Brian Doyle-Murray, Ramis and Douglas Kenney. It stars Chevy Chase, Rodney Dangerfield, Ted Knight, Michael O'Keefe and Bill Murray. Brian Doyle-Murray, Bill Murray's elder brother, also has a supporting role. The official cast listing also includes 'Chuck Rodent' as Mr. Gopher.

Rufus Griffin is mentioned as starring in Caddyblack, a blaxploitation version of Caddyshack in "If I'm Dyin', I'm Lyin'".

In "North by North Quahog", Brian is watching the kids while Lois and Peter are away. To stop Meg and Chris from fighting, Brian reads the novelization of Caddyshack to them, after finding out it's one of the few books Peter owns.

In "Blind Ambition", Stewie throws paper wads into a cone Brian is wearing to keep him from chewing out his stitches. He says "If I make this, we're all going to get laid." At the end of Caddyshack, Rodney Dangerfield says "Hey everybody, We're all going to get laid."

Peter “swam with the bulls” in "Brian Sings and Swings". They perform to “Waltz of the Flowers” from the ballet The Nutcracker by Tchaikovsky, which is a reference to the film.

Peter’s line, “So what? So let’s dance!” in "Peter's Two Dads" was also used by Rodney Dangerfield in Caddyshack.

"Meet the Quagmires" recalls a scene from the movie with Lois strutting poolside to the Kenny Loggins song "Mr. Night".

Stewie references the movie in his song "I've Got a Little List" in "Lois Kills Stewie".

Wil Wheaton and Patrick Stewart's exchange in "Not All Dogs Go To Heaven" at the McDonald's drive-thru is a directly from Caddyshack.

The scene in the warden's office with the lamp in "Three Kings" is taken from Caddyshack.

Knight appears as Judge Smalls in archive footage from Caddyshack in It's A Trap!, expressing impatience with everyone's signals to attack Jabba the Hutt.

At the end of "Livin' on a Prayer", Lois gets Scotty's parents to treat their son's cancer and Peter says Rodney Dangerfield's quote "Hey everybody! We're all gonna get laid!" and the crowd cheers.