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Dharma & Greg is an American television situation comedy co-produced by Chuck Lorre Productions, More-Medavoy Productions and 4 to 6 Foot Productions in association with 20th Century Fox Television for ABC. It first aired from September 24, 1997, to April 30, 2002, and starred Jenna Elfman and Thomas Gibson as Dharma and Greg Montgomery, a couple who married instantly on their first date despite being complete opposites.

In There's Something About Paulie, the Griffins are shown watching the sitcom Dharma and Greg.

In the introduction to Family Guy Viewer Mail, Stewie keeps pushing a button on a laugh box. When Brian asks Stewie where he got the gizmo, he says he got it from the frequently maligned ABC sitcom Dharma & Greg. Brian jokingly declared he was surprised that there was anything left in it. ABC has been looked down upon for allegedly overusing a bad laugh track in their comedies.

In The Family Guy 100th Episode Special, Seth MacFarlane comments "Welcome back to the Family Guy 100th Episode Celebration. Aren't you glad this isn't the Dharma & Greg clip show? Because by now, you would have already seen the Dharma clips and you'd be stuck watching the Greg clips. God, what an awful, awful show."

Show writer Patrick Meighan previously worked on Dharma and Greg.