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Diane! was a daytime talk show hosted by Quahog 5 News co-anchor Diane Simmons. Introduced in "Fifteen Minutes of Shame", the format is very similar to that of Maury, The Jerry Springer Show, and even The Oprah Winfrey Show. Among her guests were the Griffin Family, initiated by daughter Meg, who was constantly being embarrassed by her family. Stewie and Brian do not appear in the episode, but rather prank call the show. This appearance led to their own show, The Real Live Griffins.

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