• This episode marks the 300th written episode. It is also the first time that a milestone episode has matched the broadcast order, which only gives a single episode credit to double-length episodes such as the Star Wars parodies.
  • "It's So Hard to Say Goodbye to Yesterday" by Boyz II Men closes out the episode.
  • Peter's subplot is similar to two episodes of The Simpsons: Bart refusing to wash his hand after a girl he likes spits on it in "New Kid on the Bock", and "The Genesis Tub", a segment from "Treehouse of Horror VII", in which a micro-civilization born on Lisa's lost tooth undergoes millennia of evolution in mere days.
  • Names that Rupert called Brian:

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