Christopher Columbus (c. 31 October 1451 – 20 May 1506) was a navigator, colonizer, and explorer.
In "The Kiss Seen Around the World", Peter and Brian travel back in time to 1492 to meet Columbus in a scene that parodies the segment “Peabody’s Improbable History” on the popular cartoon show The Rocky and Bullwinkle Show. In this appearance he is voiced by Seth MacFarlane.
A deleted scene intended for "Quagmire's Baby" was recycled into "The History of the World – According to Family Guy" in the Family Guy Volume 9 DVD set of Columbus unhappy that Amerigo Vespucci was getting the continent named after him while he has to settle for Columbus, OH.