Fluffy was the replacement pet in the Griffin household after Brian left in "Brian: Portrait of a Dog". Getting a cat was proposed by the youngest child Stewie. The cat turned out to be mean and violent, throwing firecrackers at the Griffins and jumping on Peter's head, pulling his eyelids up with its claws.
Fluffy joins several other animals of the show as well as the cast in singing "Blue Shadows On The Trail" in "Wild Wild West".