Lady Macbeth is a character in William Shakespeare's Macbeth (c.1603-1607). She is the wife to the play's antagonist, Macbeth, a Scottish nobleman. After goading him into committing regicide, she becomes Queen of Scotland, and later suffers pangs of guilt for her part in the crime. She dies off-stage in the last act, an apparent suicide.
Lady Macbeth is shown in one of Peter Griffin's cutaways in "Family Goy", wrestling a bear on a spaceship. When Lois just stares at him, Peter admits he doesn't know Shakespeare very well.
During a Family Feud gag in the Romeo and Juliet segment of "Heart Burn", the Capulet's choose "Out" to go along with "Dammed spot." "Out, damned spot!" is part of a sentence from the play Macbeth, spoken by Lady Macbeth.