This is the last episode where Cleveland Jr. has any speaking lines. He would later appear redesigned, overweight, and 14 years old with all hyperactivity gone in The Cleveland Show.
Quagmire’s foot fetish is revealed in this episode.
When Chris, Meg, Peter, and Brian talk at the same time, they stop talking and then say “Ruth Bader Ginsburg” to try and trick each other. It doesn’t work.
Stewie uses Brian’s books to create papier-mâché replicas of the houseboat from the 1960s campy detective show Surfside 6 and the fort from the post-Civil War-era sitcom F Troop, another 1960s show.
Stewie mentions that one of Brian’s books is by Russian writer Fyodor Dostoevski. Brian will be seen reading Dostoyevsky in “Ready, Willing, and Disabled”.
When Cleveland Jr. plays with a stick he says “I’m Daniel Boone,” an American pioneer. When the stick breaks in half he says “Now I’m Pat Boone. Gonna have a Christmas special with Andy Williams.” Pat Boone and Andy Williams are both pop singers who reached their commercial peaks in the 1950s.
Cleveland suggests that the sitcom Fish should be put before the television series CHiPs as a good marketing strategy.
After Peter tosses Cleveland Jr. a golf ball, he begins kicking it with his feet, singing “I’m Pelé,” a mention of the Brazilian soccer player.
Cleveland Jr. sings a jingle for Honeycomb breakfast cereal.
Lois brings Brian some of Peter’s books, which include Mr. T by Mr. T, an autobiography of The A-Team star; T and Me by George Peppard, an actor who co-starred with Mr. T on The A-Team and For the Last Time, I’m Not Mr. T by Ving Rhames, an African-American actor with a physique like that of Mr. T. With the exception of Mr. T by Mr. T, all of these books are fictitious.
When encouraging himself to fight his perceived illness, Stewie tells himself “do not go gentle into that good night.” He first attributes the quote to singer-songwriter Bob Dylan but then corrects himself; it was written by poet Dylan Thomas.
When Meg asks why Stewie is freaking out, Lois explained that he is having hallucination from the fever, just like one time when Meg accidentally ate "adult" brownies presumably containing drugs that Lois was saving for the Doobie Brothers concert.
The beginning where the family watches Little House on the Prairie with the entire family playing pranks on their blind daughter is cut from the censored versions.