Franklin Delano Roosevelt (January 30, 1882 – April 12, 1945), commonly known by his initials FDR, was an American statesman and political leader who served as the 32nd President of the United States, notable for winning four terms to the office and leading the United States out of the Great Depression and through WWII.
During the song "Patriotic Weirdness" in "Peter's Sister", Jack Skellington and the citizens of Halloween Ton take over the 4th of July, celebrating with the skeletons of George Washington, Abraham Lincoln and Franklin Delano Roosevelt.
While trying to hide the fact that he isn't rich like Chadley in "Take a Letter", Stewie feels he is living a lie, like FDR. A cutaway shows Roosevelt being maneuvered with strings like a puppet, in an attempt to hide his disability caused by Polio. When he is finished, he requests to be kicked into the closet but teases the assistant about being a Yale man after it takes multiple kicks to get him inside of the closet.