Game of Thrones is an American fantasy drama television series created by David Benioff and D. B. Weiss. It is an adaptation of A Song of Ice and Fire, George R. R. Martin's series of fantasy novels.
In "Hot Pocket-Dial", Quagmire walks naked through a medieval town with Peter yelling "shame" in a reference to Game of Thrones, specifically the walk of shame done by Cersei Lannister in the episode "Mother's Mercy".
When Stewie realizes that Lois is going to be a significant part of "Hot Shots", he reminds the audience that GoT is on.
A woman complains about Peter watching GoT on a flight with the guys in "Passenger Fatty-Seven".
Peter and the guys watch the Bone Zone in "Gronkowsbees", which features only the sex scenes in television episodes. A split screen features Lizzy Caplan having sex in Masters of Sex while an albino nails a woman on Game of Thrones.