Game of Thrones, often abbreviated as GoT, is an American fantasy drama television series created by David Benioff and D. B. Weiss. It is an adaptation of A Song of Ice and Fire, George R. R. Martin's series of fantasy novels.

Peter tries to introduce culture to Meg and Chris in "The Most Interesting Man in the World" by providing them with novels that films and television shows are based on, including Game of Thrones.

Peter uses Game of Thrones in his defense of Quagmire in "Quagmire's Mom".

When Neil Goldman sits down to lunch with Chris in "Once Bitten", he compares himself and Chris to Daenerys Targaryen and Jorah Mormont from Game of Thrones.

Peter, Lois and Stewie watch Game of Thrones on BET in "No Country Club for Old Men".

In "Hot Pocket-Dial", Quagmire walks naked through a medieval town with Peter yelling "shame" in a reference to Game of Thrones, specifically the walk of shame done by Cersei Lannister in the episode "Mother's Mercy".

When Stewie realizes that Lois is going to be a significant part of "Hot Shots", he reminds the audience that GoT is on.

A woman complains about Peter watching GoT on a flight with the guys in "Passenger Fatty-Seven".

Peter and the guys watch the Bone Zone in "Gronkowsbees", which features only the sex scenes in television episodes. A split screen features Lizzy Caplan having sex in Masters of Sex while an albino nails a woman on Game of Thrones.

In "The Peter Principal", Brian recalls being on the night watch and that opening a bed & breakfast couldn't be any worse than when he joined it.

Peter incorporates elements from GoT into "Emmy-Winning Episode" including a white walker and a dragon in an attempt to win a drama Emmy.

Holden and his fate in "Don't Be a Dickens At Christmas" are a reference to Hodor in Game of Thrones and the 6th season episode "The Door", in which the latter's death while being urged to "hold the door" causes a mental link to his younger self to result in mental damage. Peter notes that his friend Holden died before GoT aired.