Ganesha, also known as Ganapati and Vinayaka, is one of the most widely-known deities in the Hindu pantheon. Although he is known by many attributes, Ganesha's elephant head makes him easy to identify. Ganesha is honored as the patron of arts and sciences and the deity of intellect and wisdom.

When Stewie and Brian travel to India after the latter falls for the voice of a technical support representative in "Road to India", Stewie jokes about getting sandwiches at a "new deli," making a pun out of the capital of India, New Delhi. Ganesha performs a rimshot at the joke, for which Stewie thanks him.