The Genie appears in the "Family Guy Viewer Mail No. 1" segment "No Bones About It". When Peter Griffin opens a can of Pawtucket Patriot Ale, the genie appears and grants him three wishes. He first wishes to see what Kelly Ripa looks like off camera and sees she is a heart-eating alien. He then wishes for his own theme music and proceeds around town until he meets an angry bus passenger who threatens to break every bone in Peter's body. Peter uses his third wish for no bones and becomes a blob. The genie then moves on, as with the inadvertent third wish, the offer to Griffin had expired.

Genie is voiced by Wally Wingert.