Genital Hospital is a pornographic movie that Chris Griffin, his friends, and brother Stewie, stole from the pornographic movie store, and later watched in "Prick Up Your Ears". When mom Lois caught them, it prompted her to revive the sex education program at James Woods Regional High School.

In the scene, a woman is diagnosed with nymphomania. The doctors tell her to take "two of these". The sound of an unzipped zipper follows.