Ghost is a 1990 romantic drama film starring Patrick Swayze, Demi Moore, Tony Goldwyn and Whoopi Goldberg, written by Bruce Joel Rubin and directed by Jerry Zucker. It was nominated for multiple Academy Awards, including Best Picture, winning for Best Original Screenplay, as well as Best Supporting Actress for Whoopi Goldberg.

In "The Story on Page One", Peter Griffin is a Ghostbuster and interrupts the famous potter wheel scene in the movie and sucks up Sam, played by Swayze.

"Baby Not On Board" also reenacts the potters wheel scene while Peter is getting a massage, using his flab to form a vase instead of clay.

In "Brian's Got a Brand New Bag", the screeching demons that take away the newly deceased Willy take Joe Swanson.

Peter falls asleep after watching a Patrick Swayze Christmas movie and dreams he is visited by Patrick's ghost in "Don't Be a Dickens At Christmas", which contains several references to the film Ghost.

When Peter dies in "Are You There God? It's Me, Peter", God offers him a chance to do pottery while straddling present-day Demi Moore. Peter passes on the offer and notes that her back bones might hurt his tummy.