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Glenn Close (born March 19, 1947) is an American film, television and stage actress, winning three Emmy Awards, three Tony Awards and received six Academy Award nominations for performances such as in The Real Thing, The Big Chill and The Natural.

Close provides her own voice in "A Lot Going On Upstairs" when Stewie dreams he is at one of her dinner parties until he is frightened by a monster that inhabits his dreams. Later, he arranges for Brian to enter into his mind while he dreams and he runs into Glenn Close as well, giving her his opinion of her performance of Cruella De Vil in the live action version of 101 Dalmatians. Over salad, she claims she can be silly, as opposed to all of the serious films that she usually does and demonstrated by saying the word "fart" for Brian.