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In "Hell Comes to Quahog" it is run out of business by Superstore USA, but reopens when the store franchise shuts down at the end of the episode. It is revealed it is located next to Cleveland's Deli.
In "Long John Peter", Peter and his band of pirates loot and pillage the pharmacy.
Meg attempts to hold up Mort in "Dial Meg for Murder".
In "And Then There Were Fewer", it is revealed that James Woods talked Mort's wife Muriel into selling him drugs for him and his girlfriend.
After Muriel's death, Mort finds himself in financial trouble in "Burning Down the Bayit" as he isn't able to cheat the customers the way she could. With Peter and Quagmire, they plot to burn down the pharmacy to collect the insurance. But Peter slips up and Joe arrests them, only to let them free when they bring back memories of how an insurance company screwed Joe after his paralyzing accident.
Mort re-opens the pharmacy in "Tea Peter".