Gremlins is a 1984 American horror comedy film directed by Joe Dante, released by Warner Bros. The film is about a young man who receives a strange creature called a Mogwai as a pet and names it Gizmo, which then spawns other creatures who transform into small, destructive, evil monsters. This story was continued with a sequel, Gremlins 2: The New Batch, released in 1990.

In "The Tan Aquatic with Steve Zissou", Peter Griffin feeds a mogwai a drumstick after midnight, causing it to turn into Fran Drescher, whose head Peter then microwaves.

In "Internal Affairs", Peter and Quagmire watch Gremlins on Quahog Channel 5 at The Drunken Clam as part of Movie and a Bath With a Guy Named Lou.

Another Mogwai appeared in "Valentine's Day in Quahog" with all of Brian's ex-girlfriends and gets offended by him.

Peter cites possibly being eaten by gremlins as his justification for refusing to eat healthy in "Saturated Fat Guy".