Hogan's Heroes is a television sitcom that aired for six seasons on CBS from September 17, 1965 to April 4, 1971. The premise is that prisoners of a POW camp during World War II, led by Col. Robert Hogan (Bob Crane), make fools out of their bumbling captors. In spite of controversy over depicting Nazis as incompetent boobs, the series was very popular and Werner Klemperer won two Emmy Awards for his role of Col. Wilhelm Klink.

In "Peter, Peter, Caviar Eater", as Brian is helping Peter to become a gentleman for the forthcoming auction by starting with polite conversation, Peter instead mentions Bob Crane' death from having his skull crushed during rough sex.

Paddy Tanniger is shown to have a secret tunnel like Hogan's Heroes in "Fore Father".

In "Emission Impossible", after seeing Stewie emerge from the Peter robot, Cleveland utters Sergeant Schultz's catchphrase, "I seen nothing. Nothing!"

Cleveland Brown playing a black Nazi in "I Take Thee Quagmire" is similar to Sergeant Kinchloe played by Ivan Dixon, a black man, frequently and successfully impersonated Nazi officers on the show.

Richard Dawson references his role on Hogan's Heroes of Sgt. Newkirk in "Big Man on Hippocampus" when he notes he served in the fictitious military.

At the beginning of "Be Careful What You Fish For" a live-action clip of Sergeant Schultz is used for the Channel 5 News report of Mercedes cars found at the bottom of the ocean.