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The Hotel Niagara is where Joe and the guys stay when he takes them on a trip with him to Niagara Falls, unaware that he plans to commit suicide after becoming depressed in "#JOLO" about being handicapped.
After two failed attempts to thrown himself into the falls, the guys are forced to restrain him by tying him to a hotel bell cart. They consider taking him back to Quahog to get help, but decide to go siteseeing while at the falls first.