The title is a reference to the phrase, "If I'm lyin', I'm dyin'."
Gumbel 2 Gumbel shares elements with 1980s TV shows such as Miami Vice and Hart to Hart, and also has reference to the TV show Pacific Blue.
In the NBC boardroom, one of the men suggests that they have a new show about a single white girl in the city working at a magazine. This is much like many of the sitcoms aired on NBC at the time of this episode, particularly Just Shoot Me! and Suddenly Susan, which is why one of the executives dismisses the idea as "the same crap over and over" and suggests that they "take a chance" and "do something fresh," to which the dissident is beaten with a Just Shoot Me! poster.
Peter's black cousin Rufus Griffin had starred in many movies called Caddyblack, Blackdraft, and Black Kramer vs. Kramer. These are parodies of the movies Caddyshack, Backdraft, and Kramer vs Kramer, respectively as well as a reference to the way that the title of Dracula was modified to make the title of Blackula. Back to the Future is spoofed with Peter's black cousin, Rufus Griffin in a blaxploitation film called Black to the Future. The De Lorean time machine, meeting up with his teenager mother, and performing at the school dance are spoofed in the scene. The Chuck Berry phone call during the dance is replaced with the band member calling Isaac Hayes instead.
The 1970s sitcom Good Times is parodied in a scene where Florida Evans is upset that she's named after a U.S. State. J.J.'s infamous "Dy-No-Mite" is also implemented.
After Chris shows signs of boils, one of the ten Plagues of Egypt, one of the names Peter said kids used to call him was "Rootin' Tootin' Raspberry." This is a reference to the Pillsbury Funny Face Drink flavor.
In the scene where Peter is pleading to God, he mentions he says "I'm just a big fake, like the Moon Landing, Marky Mark's dong in Boogie Nights, and Tom Cruise and Nicole Kidman not the completely untrue gay thing, but they're both just really phony." These are references to the Apollo Moon Landing hoax accusations, Tom Cruise and Nicole Kidman's marriage which at the time of the episode's original airing they were still married, and to the ending to Boogie Nights in which Wahlberg's character Dirk Diggler pulls out his long penis. In fact, according to Wahlberg in an interview on Inside the Actor's Studio, he was actually holding a prosthetic, made out of rubber, in front of his real genitals. He kept the object as a souvenir from the filming.