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Jack and Jill is a traditional English nursery rhyme. The first and most commonly repeated verse is:
- Jack and Jill went up the hill
- To fetch a pail of water.
- Jack fell down and broke his crown,
- And Jill came tumbling after.
In "Stewie Is Enceinte", Stewie feels like he and Brian are growing apart after years of being inseparable, like Jack and Jill. In a cutaway Jack and Jill are shown hosting friends, while being passive-aggressive towards one another, telling embarrassing stories in relation to their fall.