He was involved with Lois Pewterschmidt, now married to Peter Griffin, in an intimate relationship over 20 years before the episode took place. Peter accidentally burned down Jerome's house, so Lois invited him to come live with them. Peter believed that Jerome was trying to steal Lois from him and became jealous. He kicked Jerome out of his house, but later apologized to him, and they remained friends. Jerome also tells Peter that he had some nasty ass sex with Meg when he was staying with the Griffins although Peter told him that he doesn't care about that.
He returns in "Save the Clam" playing for Mort Goldman's softball team against Peter and his team. He accidentally kills Horace after a ball Jerome hits strikes him in the face. He appears at the funeral, where he states he apologizes for killing Horace. He later takes over owning Horace's bar The Drunken Clam with his sports earnings from lacrosse, which also happens to be his brother's name.
After Peter becomes the star of an anti-smoking campaign in "Secondhand Spoke", Jerome mounts his picture in The Drunken Clam along with black celebrities.
Jerome has strong reservations when his daughter Pam starts to date Chris Griffin in "Baby Got Black". When he finds his own racism reflected in Peter's advice to Chris, he relents on letting them see each other. Jerome's age is revealed to be 42.
Jerrome attempts to "upgrade" the bar food in "Pilling Them Softly".
In "Follow the Money", Jerome reveals that he lost both his childhood sweetheart and their daughter shortly after their wedding.
Jerome faces having to close the Drunken Clam for up to a month after his mother suffers a stroke in "The Woof of Wall Street" and needs to travel to Long Island to be with her. Peter and the guys volunteer to run the place while he's away, but a bull that Peter brings into the bar wrecks the place and destroys Jerome's only image of his mother, a painting that he keeps. When she passes away, the guys try to construct dummies of themselves for Jerome to beat up on his return, but Peter ends up inside the bar while his dummy is safe outside.
- FG807 "Jerome Is the New Black"
- FG1119 "Save the Clam"
- FG1201 "Finders Keepers"
- FG1208 "Life of Brian" (Uncensored version)
- FG1211 "Brian's a Bad Father"
- FG1215 "Secondhand Spoke"
- FG1218 "Baby Got Black"
- FG1301 "The Simpsons Guy"
- FG1304 "Brian the Closer"
- FG1306 "The 2000-Year-Old Virgin"
- FG1314 "#JOLO"
- FG1316 "Roasted Guy"
- FG1401 "Pilling Them Softly"
- FG1414 "Underage Peter"
- FG1415 "A Lot Going On Upstairs"
- FG1418 "The New Adventures of Old Tom"
- FG1419 "Run, Chris, Run"
- FG1502 "Bookie of the Year" (mentioned)
- FG1511 "Gronkowsbees"
- FG1514 "The Dating Game"
- FG1601 "Emmy-Winning Episode"
- FG1604 "Follow the Money"
- FG1606 "The D in Apartment 23"
- FG1608 "Crimes and Meg's Demeanor"
- FG1615 "The Woof of Wall Street"