He was involved with Lois Pewterschmidt, now married to Peter Griffin, in an intimate relationship over 20 years before the episode took place. Peter accidentally burned down Jerome's house, so Lois invited him to come live with them. Peter believed that Jerome was trying to steal Lois from him and became jealous. He kicked Jerome out of his house, but later apologized to him, and they remained friends. Jerome also tells Peter that he had some nasty ass sex with Meg when he was staying with the Griffins although Peter told him that he doesn't care about that.
He returns in "Save the Clam" playing for Mort Goldman's softball team against Peter and his team. He accidentally kills Horace after a ball Jerome hits strikes him in the face. He appears at the funeral, where he states he apologizes for killing Horace. He later takes over owning Horace's bar The Drunken Clam with his sports earnings from lacrosse, which also happens to be his brother's name.
He is voiced by Kevin Michael Richardson.