John Sidney McCain III (born August 29, 1936) is the senior United States Senator from Arizona. He was the Republican nominee for President in the 2008 United States election, losing to Barack Obama.

The John McCain Experience was a small ride Peter Griffin went on in the episode "Padre de Familia". It starts off with the person being locked in a cage, then being continuously poked by a Vietnamese person, until they claim that they want to be President of the United States.

In "Road to Germany", Stewie Griffin found a McCain/Palin campaign button in his Adolf Hitler disguise.

John McCain appeared in "Excellence in Broadcasting" at the Republican National Headquarters. As a parody of Scooby-Doo, it is revealed he and Rush Limbaugh solve mysteries together with the help of Hot Dog. In one, Democrat Congressman Barney Frank is the monster behind the mask.