From this episode forward, Peter is employed as a shipping clerk at the Pawtucket Pat Brewery. It was last seen in “Wasted Talent” in a spoof of Willy Wonka and the Chocolate Factory and has changed since Pawtucket Pat sold it. Chris also becomes a freshman at James Woods High.
Peter’s ideal jobs are cowboy, astronaut, warlock, more powerful astronaut, and beer expert. This is mentioned in a further episode “Patriot Games” when Peter pretends to be a “Secret Agent Cowboy Astronaut Millionaire” in order to impress his old friends at a high school reunion.
At the beginning of the episode, Peter and his friends watch an episode of the HBO western drama Deadwood, which puns on the word wood, which is slang for erection.
When Lois tries to recall which of the family’s acquaintances was in the Peace Corps, Peter suggests actor Beau Bridges who was never in the Peace Corps.
In a cutaway, Peter was Kevin Federline’s magic mirror. In which he told Kevin to not shave or shower, keep wearing his tank top that he slept in all day, and walk around with an undeserved sense of accomplishment after Kevin asked Peter how he can "look like a douchebag" that day.
Peter asks Chris who was the female star of in the 1980’s detective series Remington Steele. Chris correctly points out that it was Stephanie Zimbalist.
Peter pays the natives to reenact the episode “The Contest” from the NBC sitcom Seinfeld. The line spoken by the high priestess playing Elaine, however, is from another episode, “The Stall”.
In a cutaway, Stewie tours Europe with a musical rendition of My Left Foot, Irish author Christy Brown’s memoir of his struggle with cerebral palsy, which was turned into an acclaimed 1989 film starring Daniel Day-Lewis.
Chris mentions Lou Gehrig being a hero, a clip is then shown of Lou creating a poison he calls Lou Gehrig’s disease to enslave the Earth. The poison then spills on Gehrig causing him to contract the disease, he is then shown in a wheelchair, realizing the karmic irony.
Peter has a flash-back to when he was an assistant to Dr. Bunsen Honeydew, showing Peter morphed into a Beaker design and meeping. Bunsen laughs and agrees with Peter.
There is an extended sequence in which Stewie flies to Los Angeles to punch actor/comedian Will Ferrell for his role in the 2005 film remake of the television series Bewitched, which generally opened to poor reviews. The writers of the show stated in the DVD commentary for this episode that they like Ferrell, but they hated the film remake and felt let down by him. They also mentioned that the joke was originally Stewie going to beat up Steve Martin after seeing him in Bringing Down the House. Ferrell had previously guest starred in “Fifteen Minutes of Shame” and “Mr. Saturday Knight”.