The effects of toad licking cause one of the teenagers to “finally get” Aaron Sorkin’s cult television show Sports Night; “It’s a comedy that’s too good to be funny,” referring to the show’s complex but dry humor. Coincidentally, Sorkin was arrested a year later for possession of hallucinogenic mushrooms.
The Griffins watch a Doublemint Gum commercial featuring conjoined twins, a parody of the brand’s commercials featuring identical twins.
A slang term for licking toads is “Doing Kermit,” a reference to Kermit the Frog.
The anti-toad licking public service announcement parodies a classic Tootsie Pop ad.
In a cutaway to “the good old days” of public education a girl correctly recites the quadratic formula, causing the class to deem her a witch and stone her. This is a reference to the Salem witch trials and the atmosphere of sexism and paranoia that facilitated it.
Lando fakes his way through saying slang terms, one of them being “Poppin’ Fresh,” a reference to Pillsbury.
Peter spray paint's “Thompson Twins Rule” on a school wall, referring to a 1980s new wave band. This is also a reference to the opening credits of The Fresh Prince of Bel-Air where Will Smith is spray-painting an “F” on a wall and a cop catches him, with Will getting out of being blamed by pointing out the “F” was already on the wall and he was using the spray-paint can as a can of spray-on deodorant.
When Meg confronts “Lando” about why he has broken his promise to take her to the dance, he says “Something suddenly came up!” This is what Marcia Brady's date said to her when he changed his mind about taking her to the dance after breaking her nose with a football and seeing it swell up, on The Brady Bunch.
Stewie replays his own version of Oliver Twist's famous request: "Please, sir, I want some more."
Peter resolves to “fight for my right to party,” referencing the Beastie Boys’ 1986 release “You Gotta Fight for Your Right (To Party)”.
Peter’s sneaking out of his room is a parody of Fast Times at Ridgemont High’s Stacey sneaking out of her house, with the soundtrack featuring a ripoff of Jackson Browne’s “Somebody’s Baby”, which featured in the original film.
“Lando” says goodbye to his classmates saying “I will ride recklessly into the night, and up Dead Man’s Curve,” parodying the climax of the 1982 film Grease 2.
The ending of the episode mirrors the ending of The Breakfast Club, including the song “Don’t You (Forget About Me)” by Simple Minds.