Stewie references an incident where Kevin Smith was removed from a Southwest airline flight for being oversized. 
Mayor West claims he is musician John Mayer and references Mayer's song Your Body Is a Wonderland.
When Lois gets Scotty's parents to treat their son's cancer, Peter says Rodney Dangerfield's quote from Caddyshack "Hey everybody! We're all gonna get laid!."
The cutaway gag involving a vampire in San Francisco is reminiscent of an 80's era Saturday Night Live skit about a vampire who is paranoid about catching AIDS, so he arranges to have a woman's blood sample tested before biting her. Unfortunately the test takes too long and the sun comes up before he can complete the deed. James Woods, a frequent guest on Family Guy, was the guest host in that episode and performed as the vampire.