Stewie mentions that Sheldon without his shell to a "nude Larry David", comparing him to the co-creator of Seinfeld.
Lois celebrates her 43rd birthday in the episode.
Sheldon inadvertently saves Meg's life by swapping her sleeping pills with Alka-Seltzer tablets, foiling her suicide attempt.
Lois' tattoo on her back says "Serenity."
Alex Borstein was nominated at the 65th Primetime Emmy Awards for Outstanding Voice-Over Performance for playing Lois Griffin and Tricia Takanawa in this episode. She lost to Lily Tomlin for narrating the HBO documentary An Apology to Elephants.