• This is the second time Lois has a midlife crisis, after "Go, Stewie, Go!".
  • "Conway Bieber" sings "Only Make Believe".
  • Stewie mentions that Sheldon without his shell to a "nude Larry David", comparing him to the co-creator of Seinfeld.
  • Lois celebrates her 43rd birthday in the episode.
  • Sheldon inadvertently saves Meg's life by swapping her sleeping pills with Alka-Seltzer tablets, foiling her suicide attempt.
  • Lois' tattoo on her back says "Serenity."
  • Alex Borstein was nominated at the 65th Primetime Emmy Awards for Outstanding Voice-Over Performance for playing Lois Griffin and Tricia Takanawa in this episode. She lost to Lily Tomlin for narrating the HBO documentary An Apology to Elephants. [1]

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