Mary Baker Eddy (July 16, 1821 – December 3, 1910) was the founder of Christian Science (1879), a Protestant American system of religious thought and practice religion adopted by the Church of Christ, Scientist, and others. She is the author of the movement's text book, Science and Health with Key to the Scriptures, and founded the Christian Science Publishing Society (1898), which continues to publish a number of periodicals including The Christian Science Monitor (1908).

In "Livin' on a Prayer", Peter and Lois Griffin encounter Christian Scientists Hope & Ben Jennings who refuse to allow their son Scotty to get professional medical help, instead, relying on prayer. They show the family the book Science and Health with Key to the Scriptures as the key to their beliefs. Peter later reads it and becomes fascinated with the idea of praying for what he wants, imagining himself as Cathrine Middleton on the day of her wedding to Prince William.