McDonald's Corporation, is the world's largest chain of fast-food restaurants serving burgers, fries, and shakes. McDonald's is headquartered in Oak Brook, Illinois.
In "Not All Dogs Go To Heaven", Stewie took the cast of Star Trek: The Next Generation there for lunch. Marina Sirtis tells Stewie that she's not a fast-food eater. Brent Spiner asks for McNuggets, while Wil Wheaton asks for a cheeseburger, a hot dog and a milkshake. Stewie then orders two McChicken sandwiches and a diet coke. He asks Michael Dorn what he wanted and Michael asks for a McDLT which was discontinued in 1990.
Mayor McCheese seeks plastic surgery in "Believe It or Not, Joe's Walking on Air". Dr. Hartman rejects his request since McCheese has a cheeseburger for a head. McCheese thanks Dr. Hartman for telling him the straight facts.
In "Cool Hand Peter", it's parodied as McDaniel's.
In "JOLO", the Griffins get excited over the return of the McRib.
A cutaway gag in "Cop and a Half-Wit", shows Orson Welles performing his The War of the Worlds broadcast outside of a McDonald's to encourage the crowd to leave, while at the same time, trying to keep the staff in place.