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Miss Lorelei Piggy is a Muppet character who was primarily played by Frank Oz on The Muppet Show. In 2001, Eric Jacobson began performing the role, although Oz did not officially retire until 2002.
When Brian tries to point out to Stewie that it isn't easy to work with an ex in "The Boys in the Band", a cutaway gag shows Scooter asking Miss Piggy about calling in sick the previous day. As she brushes it off with humor about having a "frog in her throat" while giving Kermit the Frog a poke in the ribs, he tiredly suggests she quit drinking.