Mrs. Butterworth is the corporate mascot of the brand of pancake mixes and syrups that bear her name. They syrup products are issued in bottles that are shaped in her likeness.

When Peter acts particularly dumb in "A House Full of Peters", Lois sighs at not being the only one with a useless husband. In a cutaway gag, Mrs. Butterworth's husband objects to having her name instead of his and she points out that it is her earnings that support his 'hobby.' As he objects, he gets a call for his 'business' of 'lamps that look like soccer balls.' When the customer makes a return on his items, he resigns himself to being 'Mr. Butterworth.'