Ms. Clifton is a former teacher of Chris Griffin at Buddy Cianci Junior High School. She won the lottery in "Fast Times at Buddy Cianci Jr. High". She quickly ran out of the classroom to collect her winnings and quickly resigned and retired. Initially, Brian was chosen to replace her temporarily, but his assignment was switched. Brian was replaced with Mrs. Lockhart.
Ms. Clifton is voiced by Juanita Jennings.