Nancy Patricia D'Alesandro Pelosi (born March 26, 1940) is an American politician who is the current Minority Leader of the United States House of Representatives. Pelosi served as the 60th Speaker of the United States House of Representatives from January 4, 2007 to January 3, 2011. She was the first woman to hold the office and the highest-ranking female politician in American history.

When Rush Limbaugh refuses to join Brian Griffin in going down to Washington to face Pelosi in "Excellence in Broadcasting", Brian takes it upon himself. She is caught attempting to smoke crack cocaine, but then immediately has Brian arrested and thrown in the County Jail.

She is voiced by Nana Visitor.