Dr. Niles Crane, M.D., Ph.D., A.P.A. is a fictional character on the American sitcom, Frasier, a spin-off of the popular show, Cheers. He was portrayed by David Hyde Pierce. Niles is the younger brother of Frasier Crane.

In "Peter, Peter, Caviar Eater", Brian forces Peter to watch an episode of Frasier in an attempt to teach him how to act with class.

Niles and Frasier appear when Peter doubts Meg's claim of modeling in "This Little Piggy", claiming that her only chance of fame would have been as the dog on Frasier.